1
10
573
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https://d1y502jg6fpugt.cloudfront.net/25425/archive/files/1b80450de0799bf0ebeaa76506724960.pdf?Expires=1712793600&Signature=q%7EeX3EJ0thoKUJWjQ9MWna-fF9SOWgfNE9yJZW%7EtiD0Dt1vCkL1pC-dmBjPeslL29Irk8uG3eNwcZR4Ggb4z6aHuk%7EoFJzzeh87pqRMKpCR6wbyn2vp5WQBJz5f5UzTgjOWGg7cETtleHY7my%7EvIy7LTZd%7Ekk49yQEzxojwiymut9YMcWS0rPsUZiQy2RsjfveLwJsuMjo4wrhLSbfAsWpNtG3Fmxq7eWMQXGBWRqk0wrOMqy7cFSZnh5CGh3pn%7E5axxOIjei2HNNxmpiEQw1fl921dMW3Tfe-L-0TIxraoyxLT8pX9w7LocHDSfvcadas4q1R2gcvaEh-eOT3uSWA__&Key-Pair-Id=K6UGZS9ZTDSZM
4515c63bab480b57b1833f902e6ba3be
Dublin Core
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Title
A name given to the resource
Assessment of the Biofield Energy Healing-Based Proprietary Test Formulation for Energy Boosting Biomarker-ATP in MG63 and C2C12 Cell Lines
Subject
The topic of the resource
Health & Wellness
Description
An account of the resource
The objective of the present study was to evaluate the effect of the Trivedi Effect®- Biofield Energy Treated Test formulation (TI) containing minerals (magnesium, zinc, copper, calcium, selenium, and iron), vitamins (ascorbic acid, pyridoxine HCl, alpha tocopherol, cyanocobalamin, and cholecalciferol), Panax ginseng extract, CBD isolates, and β-carotene on ATP levels in human osteoblast (MG-63, Osteosarcoma) and mouse myoblast (C2C12) cell lines. The constituents of the test formulation were divided into two parts; one section was defined as the untreated test formulation (UT), while the other portion of the test formulation received Biofield Energy Healing Treatment (BT) by a renowned Biofield Energy Healer, Mr. Mahendra Kumar Trivedi. The test items were treated with Biofield Energy Healing Treatment and known as Biofield Energy Treated (BT) test items. MTT results showed that the test formulation in various concentrations was found as safe and nontoxic, with the viability range from 82% to 159%. However, the level of adenosine tri phosphate (ATP) in MG63 cells was increased by 146.9% (at 0.001 μg/mL) in the UT-DMEM+BT-TI group as compared with the UT-DMEM+UTTI group. However, 79.6%, 111.9%, and 180.7% increased the level of ATP was reported at 0.1, 1, and 10 μg/mL, respectively in the BTDMEM+UT-TI group, while 456.9%, 91.5%, and 123.4% increased ATP level was reported at 0.001, 0.01, and 0.1 μg/mL, respectively in the BT-DMEM+BT-TI group as compared with the UT-DMEM+UT-TI group in MG63 cells. Similarly, in the C2C12 cell lines were also reported with significant increased the ATP level by 178.7% at 1 μg/mL in the UT-DMEM+BT-TI group compared to the UTDMEM+UT-TI group. Further, the ATP level was increased by 637.5%, 240.1%, and 26.8% at 0.001, 0.01, and 0.1 μg/mL, respectively in the BT-DMEM+UT-TI group as compared to the UT-DMEM+UT-TI group. Moreover, the ATP level was increased by 776.2%, 22.9%, 234.2%, and 24.5% at 0.001, 0.01, 0.1, and 1 μg/mL, respectively in the BT-DMEM+BT-TI group as compared with the UT-DMEM+UTTI group. Overall, data suggested that there was significant improvement of ATP level in the Biofield Energy Treated test formulation as well as Biofield Treated DMEM medium. Therefore, the results suggest that the Biofield Energy Treated test formulation and/or the Biofield Energy Treated DMEM medium can be used as energy booster and also it can improve the mental stamina, endurance, and physical strength of the muscles to show the better performance.
Creator
An entity primarily responsible for making the resource
Trivedi MK, Branton A, Trivedi D, Nayak G and Jana S
Source
A related resource from which the described resource is derived
<a href="https://www.researchgate.net/publication/376858464_Assessment_of_the_Biofield_Energy_Healing-Based_Proprietary_Test_Formulation_for_Energy_Boosting_Biomarker-ATP_in_MG63_and_C2C12_Cell_Lines">https://www.researchgate.net/publication/376858464_Assessment_of_the_Biofield_Energy_Healing-Based_Proprietary_Test_Formulation_for_Energy_Boosting_Biomarker-ATP_in_MG63_and_C2C12_Cell_Lines</a>
Publisher
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Annex Publishers
Date
A point or period of time associated with an event in the lifecycle of the resource
March 03, 2020
Language
A language of the resource
English
Type
The nature or genre of the resource
Journal Article
ATP
Biofield Treatment
C2C12
Energy Panel
MG63
The Trivedi Effect®
-
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Title
A name given to the resource
Case report: Biofield photon energy-antibiotic therapy for pyometra in Belgian Malinois dog
Subject
The topic of the resource
Life Sciences
Description
An account of the resource
We describe management of pyometra in a 2-year-old Belgian Malinois dog in 8-week gestation. The dog presented with fleas, dermatitis, pruritis, depression and swollen vulva with foul-smelling vaginal discharge suggesting pyometra. Digital radiography showed no viable fetuses at 8th week pregnancy but scanning suggested abortions or miscarriages due to pyometra. Findings were confirmed by X-ray, blood analysis and aborted fetuses. The dog was treated daily 63mg/kg clavamox orally for 28 days at morning and 375 mg/kg at evening, 136mg/kg enrofloxacin daily 21 days and 60 mg/kg galliprant per for 7 days to reduce pain and inflammation. Dog was also subjected to Trivedi’s Biofield Energy Treatment. After treatment, dog exhibited rapid recovery, resumed normal activities, consumed regular diet, and showed marked improvement in clinical symptoms and overall physical health. At 11-weeks, she delivered 13 healthy puppies.
Creator
An entity primarily responsible for making the resource
Shailendra Patil, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Alan Balmer, Sambhu Mondal, Snehasis Jana
Source
A related resource from which the described resource is derived
<a href="http://onljvetres.com/pyometradogabs2023.htm">http://onljvetres.com/pyometradogabs2023.htm</a>
Publisher
An entity responsible for making the resource available
Pestsearch Int Pty Ltd
Date
A point or period of time associated with an event in the lifecycle of the resource
December 2023
Language
A language of the resource
English
Type
The nature or genre of the resource
Journal Article
Biofield Energy Treatment
Bitch
Gestation
Pyometra
Viable Puppies.
-
https://d1y502jg6fpugt.cloudfront.net/25425/archive/files/17a975a461e654bd6cce863fd95c3b2d.pdf?Expires=1712793600&Signature=LF3DboDRnSYDZ3MOPZscYpZSFJ8W7fGfnP8Tl-8OlFkL7vmke0hVRHB4ymO7UiIYIn5GOQdzOv5KWIsWkQ2XWJhLtlaJwQivrTTRYWCL9RwWe4Ipqlk6wY4bwyFGdHYBj6Cin-wmXeylzGlcDjuykgvxGYeBTamz%7Ehw2RmOdm-OMnTG1A51fcErkf-g%7Ewwz8Mr9gu%7E1q6EJhHuSkqsaVh3IPSj9cCHmgvZmaoMQx1e3PLo8gqRIWUUjNfkfbNZmxGf1h%7EV8UsoNMFkET1Y3mdCanMmthDEZtkpZmxVLl9WTTLURfGKz%7EfCyDDzEwhqpfZG%7EyBq0-mjKlP0mIDMIwKg__&Key-Pair-Id=K6UGZS9ZTDSZM
bc07c610df4b143771042530a4e856c6
Dublin Core
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Title
A name given to the resource
The Potential Health Benefits of the Consciousness Energy Treated Novel Test Formulation on Various Functional Enzyme Biomarkers
Subject
The topic of the resource
Health & Wellness
Description
An account of the resource
The study objective was to investigate the effect of the Consciousness Energy Treated test formulation on vital organs like bones, heart, liver, lungs and brain using various cell-based assays. The test formulation and the cell media was divided into two parts; one untreated (UT) and other part received the Biofield Energy Treatment remotely by a renowned Biofield Energy Healer, Shirley Theresa Holmlund, Canada and was labeled as the Biofield Energy Treated (BT) test formulation/media. Cell viability data suggested that the test formulation was safe and non-toxic in six different cells. The Biofield Energy Treated Medium (BT-Med) + Biofield Treated Test Item (BT-TI) group showed 115.6% and 53.3% restoration of viable cells at 10 and 25 μg/mL, respectively in human cardiac fibroblasts cells (HCF) compared to the UTMed + UT-TI group. Moreover, the BT-Med + UT-TI group showed 113.5% and 73.5% restoration of cell viability at 0.1 and 1 μg/mL, respectively in human hepatoma cells (HepG2) compared to the untreated group. Furthermore, 101.1%, 829.8% and 698.9% restoration of cell viability was observed in adenocarcinomic human alveolar basal epithelial cells (A549) by UT-Med + BT-TI, BT-Med + UT-TI and BT-Med + BT-TI groups, respectively at 10 μg/mL compared to the untreated. The alkaline phosphatase (ALP) level was significantly increased by 97.9% and 69.7% in the UT-Med + BT-TI and BT-Med + BT-TI groups, respectively at 50 μg/mL in human bone osteosarcoma cells (MG-63) compared to the untreated. Additionally, the level of ALP was significantly increased by 58.2% in the BT-Med + BT-TI group at 1 μg/mL in human endometrial adenocarcinoma cells (Ishikawa) compared to the untreated. The percent protection of HCF (heart) cells (decreased of LDH activity) was significantly increased by 67.4% (at 0.1 μg/mL), 80.4% (at 0.1 μg/mL) and 119.8% (at 10 μg/mL) in the UT-Med + BT-TI, BT-Med + UT-TI, BT-Med + BT-TI groups, respectively compared to the untreated. The percent protection of HepG2 (liver) cells (decreased of ALT activity) was significantly increased by 57.6% and 82.5% in the BT-Med + UT-TI group at 25 and 63 μg/mL, respectively; while 123.9% at 10 μg/mL in the BT-Med + BT-TI group compared to untreated. The percent protection of A549 (lungs) cells (increased of SOD activity) was significantly increased by 53.6% and 59% in the UT-Med + BT-TI and BT-Med + BT-TI groups, respectively at 10 μg/mL compared to the untreated. Serotonin level was significantly increased by 85.3% in the UT-Med + BT-TI and BT-Med + BT-TI groups at 0.1 μg/mL as compared to untreated in human neuroblastoma cells (SH-SY5Y). The relative quantification (RQ) of vitamin D receptor (VDR) was significantly increased by 245.9% and 211.5% at 10 and 50 μg/mL, respectively in the UT-Med + BT-TI group; while 174.3% (at 10 μg/mL) in the BT-Med + UT-TI group as compared to the untreated in MG-63 cells. Overall, these results suggest that Biofield Energy Treated test formulation has significantly improved the bones, heart, liver, lungs and brain functional enzymes biomarkers. Altogether data suggest that the Biofield Energy Treatment (The Trivedi Effect®) can be useful to protect and maintain the normal function of each vital organ such as lungs, liver, heart, brain, and bones.Therefore, The Trivedi Effect® can be used as a complementary and alternative therapy against several disorders such as heart attack, coronary artery disease, heart failure, arrhythmias, congenital heart disease, cardiomyopathy, Wilson disease, hemochromatosis, cirrhosis, liver cancer, pneumonia, emphysema, chronic bronchitis, asthma, osteoporosis, cystic fibrosis, etc.
Creator
An entity primarily responsible for making the resource
Shirley Theresa Holmlund, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Sambhu Charan Mondal and Snehasis Jana
Source
A related resource from which the described resource is derived
<a href="http://www.scitcentral.com/article.php?journal=26&article=811">http://www.scitcentral.com/article.php?journal=26&article=811</a>
Publisher
An entity responsible for making the resource available
Scitcentral
Date
A point or period of time associated with an event in the lifecycle of the resource
05 April 2020
Language
A language of the resource
English
Type
The nature or genre of the resource
Journal Article
Biofield Energy Treatment
Bone Health
Brain health
Cardiac health
Liver health
Lungs health
The Trivedi Effect®
VDR receptor
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Vitamin D3 Supplementation Improves Spatial Memory, Muscle Function, Pain Score, and Modulates Different Functional Physiological Biomarkers in Vitamin D3 Deficiency Diet (VDD)-Induced Rats Model
Subject
The topic of the resource
Human Health & Wellness
Description
An account of the resource
"Background Vitamin D Deficiency is recognized as a pandemic, which is associated with high mortality. An
inadequate level of vitamin D is associated with autoimmune diseases, hypertension, and cancer. The study was
aimed to assess the pharmacological effects of chronic vitamin D3 supplementation on the manipulation diet
regiment of deprived cholecalciferol (vitamin D3 deficient diet, VDD) rats.
Methods Memory performance (Y-maze task), muscular function (muscle grip strength), and pain score (pressure
application measurement meter) were measured. Functional biomarkers were measured using ELISA method in
different matrix viz. in serum (parathyroid hormone; PTH, calcitonin, thyroxine, and C-reactive protein; CRP, 25-OH
Vit D3), and in CSF (klotho and β-endorphin). 25-OH Vit D3 was also estimated in liver and kidney homogenate using
ELISA. Vitamin D receptor (VDR) was measured spectrophotometrically in liver and adipose tissue.
Results VDD-induced rats showed a decrease in number of entries and time spent in the novel arm and
spontaneous alternations in the Y-maze task. Significant improvements of neuromuscular function and pain score
after addition of vitamin D3. In comparison to the VDD group, VDR expression (liver) and active metabolites of vitamin
D3 (25-OH vit.D3) in serum were significantly higher by 48.23% and 280%, respectively. The PTH and CRP levels were
significantly reduced by 32.5% and 35.27%, respectively, whereas calcitonin was increased by 36.67% compared with
the VDD group. Klotho and β-endorphin expressions in cerebrospinal fluid were significantly elevated by 19.67% and
133.59%, respectively, compared to VDD group.
Conclusions Overall, the results indicate that supplementation of cholecalciferol significantly improved spatial
memory impairment, VDR expression, and may provide an opportunity to manage vitamin D deficiencies."
Creator
An entity primarily responsible for making the resource
Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi,
Sambhu Mondal and Snehasis Jana
Source
A related resource from which the described resource is derived
<a href="https://bmcnutr.biomedcentral.com/articles/10.1186/s40795-023-00767-0#Sec12">https://bmcnutr.biomedcentral.com/articles/10.1186/s40795-023-00767-0#Sec12</a>
Publisher
An entity responsible for making the resource available
Springer BMC
Date
A point or period of time associated with an event in the lifecycle of the resource
Sepember 25, 2023
Language
A language of the resource
English
Type
The nature or genre of the resource
Journal Article
Cholecalciferol
Klotho
Spatial memory
VDR
Vitamin D3 deficiency diet
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Simultaneous identification and quantification of pentacyclic triterpenoids and phenolic compounds from the leaves of Boswellia serrata using LC–MS/MS tandem mass spectrometry
Subject
The topic of the resource
Material Science
Description
An account of the resource
"Boswellia serrata (B. serrata) is an important medicinal plant widely used as dietary supplements to provide a support for
osteoarthritic and inflammatory diseases. The occurrence of triterpenes in leaves of B. serrata is very little or none. Therefore,
the qualitative and quantitative determination of phytoconstituents (triterpenes and phenolics) present in the leaves
of B. serrata is very much needed. The aim of this study was to develop an easy, rapid, efficient and simultaneous liquid
chromatography–mass spectrometry (LC–MS/MS) method for the identification and quantification of the compounds present
in the leaves extract of B. serrata. The purification of ethyl acetate extracts of B. serrata was performed by solid phase
extraction method, followed by HPLC-ESI-MS/MS analysis. Chromatographic parameters of the analytical method included
negative electrospray ionization (
ESI−) with a flow of 0.5 mL/min in gradient mode consisting of acetonitrile (A) and water
(B) containing 0.1% formic acid, at 20 °C. Total 19 compounds (13 triterpenes and 6 phenolic compounds) were separated,
and simultaneously quantified using a validated LC–MS/MS method with high accuracy and sensitivity. Good linearity was
obtained with r2 > 0.973 in the calibration range. The overall recoveries were in a range between 95.78 and 100.2% with relative
standard deviations (RSD) below 5% for the entire procedure of matrix spiking experiments. Overall, there was no ion
suppression from the matrix. The quantification data showed that the total amount of triterpenes and phenolic compounds in
the leaves of B. serrata ethyl acetate extract samples ranged from 14.54 to 102.14 mg/g and 2.14 to 93.12 mg/g of dry extract,
respectively. This work provides, for the first time, a chromatographic fingerprinting analysis on the leaves of B. serrata. A
rapid, efficient, and simultaneous liquid chromatography–mass spectrometry (LC–MS/MS) method was developed and used
for the both identification and quantification of triterpenes and phenolic compounds in the leaves extracts of B. serrata. The
method established in this work can be used as quality-control method for other market formulations or dietary supplements
containing leaf extract of B. serrata."
Creator
An entity primarily responsible for making the resource
Mahendra Kumar Trivedi · Alice Branton, Dahryn Trivedi, Tarun Sharma, Sambhu Mondal, Snehasis Jana
Source
A related resource from which the described resource is derived
<a href="https://link.springer.com/article/10.1007/s44211-023-00389-3">https://link.springer.com/article/10.1007/s44211-023-00389-3</a>
Publisher
An entity responsible for making the resource available
Springer
Date
A point or period of time associated with an event in the lifecycle of the resource
June 30, 2023
Language
A language of the resource
English
Type
The nature or genre of the resource
Journal Article
Boswellia serrata
LC-ESI-MS/MS
Leaf extract
Phenolic compounds
Triterpenes
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The role of biofield energy treatment on psychological symptoms, mental health disorders, and stress-related
quality of life in adult subjects: A randomized controlled clinical trial.
Subject
The topic of the resource
Human Health & Wellness
Description
An account of the resource
"Background: Western and Eastern cultures have practiced biofield energy therapy
for thousands of years, but empirical research on effectiveness of this therapy is relatively
nascent. Study was aimed to assess the safety and efficacy of biofield therapy
on psychological symptoms and mental health disorders in adult subjects.
Methods: Seventy-seven
participants (39 male and 38 female) underwent clinical
trial. This trial was simple randomized, placebo-controlled,
parallel-group,
open-label,
and single-center
with subjects, who have one or more psychological symptoms. Two
sessions of biofield energy attunement were given in-person
at day 0 and 90 for 3 min
(treatment group, n = 35) and others allocated to naive attunement (placebo group,
n = 42). Subjects were assessed psychological questionnaire scoring using standard
scale of assessment and levels of physiological biomarkers in serum were determined
by parameter-specific
ELISA.
Results: Perceived psychological symptoms/scores (asthenia, sleep disturbances,
anxiety, depression, stress, confusion, future fearness, sexual desireness, motivation,
confidence, emotional trauma, etc.) were significantly (p ≤ 0.0001) improved in the
treatment group than placebo control group. Furthermore, physiological biomarkers:
vitamins (B12, C, and D3 metabolites), immune biomarker (CD8+CD28−), neurotransmitters
(acetylcholine, noradrenaline, and dopamine), hormones (oxytocin, 17-β-
estradiol,
and insulin), and antiaging protein (klotho) levels were significantly (p ≤ 0.001) increased
in treatment group than placebo. Proinflammatory cytokines (TNF-α,
IL-1β,
IL-6,
and IL-8)
and oxidative stress biomarkers (isoprostane and oxidized LDL) were
reduced in treatment group compared with placebo.
Conclusions: Results suggest that experimenter's biofield energy plays a significant
role in information transfer processes that contribute to individual's state of physical,
mental, emotional, and spiritual well-being
as well as improved overall health and
quality of life."
Creator
An entity primarily responsible for making the resource
Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi,
Sambhu Mondal and Snehasis Jana
Source
A related resource from which the described resource is derived
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/jgf2.606">https://onlinelibrary.wiley.com/doi/full/10.1002/jgf2.606</a>
Publisher
An entity responsible for making the resource available
Wiley online library
Date
A point or period of time associated with an event in the lifecycle of the resource
28-Jan-2023
Language
A language of the resource
English
Type
The nature or genre of the resource
Journal Article
biofield therapy
complementary therapy
mental disorder
physiological biomarker
psychological symptoms
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evaluate the Safety and Efficacy of a Biofield Energy Treated Proprietary Dietary Supplement (TRI 360™) on Psychological Symptoms, Mental Disorders, Emotional Well-being, and Quality of Life in Adult Subjects
Subject
The topic of the resource
Human Health & Wellness
Description
An account of the resource
"Background • The demand for “energy healing” is growing rapidly in the United States and other developed countries. To date, scanty clinical trials have been conducted to evaluate its clinical safety, efficacy, and cost-effectiveness.
Primary Study Objective • The study aimed to investigate the safety and efficacy of the Blessed TRI 360TM capsule (Biofield Energy Treated Proprietary Dietary Supplement Capsules Powered by the Trivedi Effect®).
Methods/Design • A total of 77 adult subjects (male and female) aged 20–45 years with one or more psychological symptoms were enrolled in the trial. The subjects were randomized into two groups: placebo control and treatment group. The treatment group (n = 35) received the Blessed TRI 360TM capsule twice a day, once in the morning and once in the evening. The placebo control group (n = 42) did not receive any treatment/capsule.
Setting • An open-label, single-center, randomized controlled trial (RCT).
Participants • Adult human subjects (male and female) with one or more psychological symptoms.
Intervention: Biofield energy treated proprietary capsule.
Primary Outcome Measures • Psychological questionnaire scores and functional physiological biomarkers. Results • Psychological and mental health symptoms were statistically and significantly reduced in the subjects taking the Blessed TRI 360TM capsule compared to the placebo group on both days 90 and 180. Furthermore, levels of functional physiological biomarkers were higher in the intervention group compared to the placebo group: vitamins (C, B12, and D3 active metabolites), neurotransmitters (acetylcholine, noradrenaline, and dopamine), hormones (17-β-estradiol, oxytocin, and insulin), antioxidant enzyme (catalase), and anti-aging protein (klotho). Additionally, proinflammatory cytokines (TNF-α, IL-1β, IL-8, IFN-γ, and IL-2), progesterone, and oxidative stress markers (MDA and oxidized-LDL) were lower in the Blessed TRI 360TM group than the placebo group after the intervention.
Conclusions • Altogether, the Blessed TRI 360TM dietary supplement capsule was found to be safe and tolerable. It significantly improved psychological symptoms and mental disorders and simultaneously improved different functional physiological biomarkers that led to an improvement in the overall health and quality of life of the adult subjects.
Clinical Trial Registration Number • ECR/147/Inst/GJ/2013/RR-16. (Altern Ther Health Med. [E-pub ahead of print.])"
Creator
An entity primarily responsible for making the resource
Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Sambhu Mondal and Snehasis Jana
Source
A related resource from which the described resource is derived
<a href="http://www.alternative-therapies.com/index.cfm/fuseaction/archives.main">http://www.alternative-therapies.com/index.cfm/fuseaction/archives.main</a>
Publisher
An entity responsible for making the resource available
InnoVision Health Media
Date
A point or period of time associated with an event in the lifecycle of the resource
9-Sep-2022
Language
A language of the resource
English
Type
The nature or genre of the resource
Journal Article
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Efficacy of a Novel Proprietary Dietary Supplement (TRI 360TM) on Psychological Symptoms and Stress-related Quality of Life in Adult Subjects: A Randomized Controlled Clinical Trial.
Subject
The topic of the resource
Human Health & Wellness
Description
An account of the resource
Nowadays, diet plays an increasingly important role in normal physiology and
mental health. Recently, many studies have shown that more use of dietary
supplements in mental and psychological disorders. Study objective was to
investigate safety and e cacy of proprietary nutraceutical combination (TRI
360TM) on psychological symptoms in adult human subjects with one or
more psychological symptoms in open-label, single-center, parallel-group,
randomized controlled trial. Eighty-four participants aged 20–45 years
with psychological symptoms were completed this trial. Participants were
randomly assigned to placebo and treatment groups. Treatment group
received TRI 360TM capsules twice a day. TRI 360TM was well-tolerated and
didn’t show treatment-related adverse-events upto 180 days. All assessed
perception scorings on psychological symptoms like fatigue, mental stress,
sleep disturbance, anxiety, depression, emotional trauma, mood changes,
self-confidence, willpower, and motivation were very significantly (p ≤ 0.0001)
improved in TRI 360TM participants than placebo control group. Furthermore,
significantly (p ≤ 0.001) increased levels of functional biomarkers: vitamin C
and D3 metabolites, neurotransmitters, hormones, antiaging protein (klotho)
level; and decreased proinflammatory cytokines and oxidative stress marker,
malondialdehyde in TRI 360TM group than placebo. According to these
findings, the use of TRI 360TM supplementation as a potentially safe therapeutic
option for reducing psychological symptoms in healthy adults.
Creator
An entity primarily responsible for making the resource
Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi,
Sambhu Mondal and Snehasis Jana
Source
A related resource from which the described resource is derived
<a href="https://www.frontiersin.org/articles/10.3389/fpsyt.2022.919284/full">https://www.frontiersin.org/articles/10.3389/fpsyt.2022.919284/full</a>
Publisher
An entity responsible for making the resource available
Frontier
Date
A point or period of time associated with an event in the lifecycle of the resource
11-Aug-2022
Language
A language of the resource
English
Type
The nature or genre of the resource
Journal Article
17-b-estradiol
dietary intervention
Klotho
mental stress
Psychological Questionnaire Scoring
TRI 360TM
tumor necrosis factor-alpha
Vitamin D3 metabolite
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cannabidiol improves thyroid function via modulating vitamin D3 receptor in vitamin D3 deficiency diet-induced rat model
Subject
The topic of the resource
Health & Wellness
Description
An account of the resource
The study was evaluated the impact of cannabidiol (CBD) on thyroid hormones by modulation cannabinoid receptor-2 (CB2) and vitamin D receptor (VDR) in rats fed with vitamin D3 deficiency diet (VDD). CB2-receptors were analyzed by RT-PCR method and others biomarkers by ELISA. The relative expression of CB2 (thyroid ~ 4 folds), VDR protein (liver, 151.72%), and (kidney, 66%) was significantly increased in CBD-60 compared to VDD. Vitamin D3 metabolites were significantly increased serum (189.42%), kidney (73.84%), and liver (58.11%) in CBD-60 than VDD. Increased thyroxine (59.9%) and calcitonin (213.59%); while decreased thyroid-stimulating hormone (36.15%) and parathyroid hormone (38.64%) was observed CBD treatment in VDD rats. In conclusion, CBD treatment improves CB2 and VDR expression and the level of vitamin D3 metabolites, along with improved thyroid hormones, including calcitonin. This is the first report with an improved CB2 and VDR expression after CBD treatment in VDD induced animals. Thus, CBD can be considered to use in hypothyroidism conditions and to maintain bone health.
Creator
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Mahendra Kumar Trivedi, Sambhu Mondal, Snehasis Jana
Source
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<a href="https://link.springer.com/article/10.1007/s13197-022-05492-3">https://link.springer.com/article/10.1007/s13197-022-05492-3</a>
Publisher
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Springer
Date
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23-Jun-2022
Language
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English
Type
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Journal Article
cannabidiol
Cannabinoid receptor
Hypothyroidism
VDR
Vitamin D3 deficiency diet
Vitamin D3 metabolite
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Title
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Effects of Cannabidiol Interactions with CYP2R1, CYP27B1, CYP24A1, and Vitamin D3 Receptors on Spatial Memory, Pain, Inflammation, and Aging in Vitamin D3 Deficiency Diet-Induced Rats
Subject
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Health & Wellness
Description
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Introduction: The study was planned to investigate memory-enhancing, anti-inflammatory, and antiaging potential of cannabidiol (CBD) on vitamin D3 deficient diet (VDD)-induced rats.
Materials and Methods: Cytochrome P-450 enzymes were analyzed by RT-PCR method and others biomarkers by enzyme-linked immunosorbent assay.
Results:CYP2R1 and CYP27B1-mRNA were significantly increased by 39.29 and 38.37%, respectively, while; CYP24A1-mRNA was significantly reduced by 21.39% compared to VDD. Vitamin D3 receptor protein expression was significantly increased by 148.3%, 60.48%, and 142.03% in liver, kidney, and brain, respectively, compared to VDD group. Vitamin D3 metabolites and serotonin were significantly increased more than 60% and 100%, respectively, compared to VDD. Spatial memory (in terms of total distance, escape latency) and pain score were improved compared to VDD. Cytokines were significantly reduced than VDD. Besides, levels of superoxide dismutase (49.61%), glutathione peroxidase (178.87%), acetylcholine (25.40%), and klotho (145.57%) were significantly increased than VDD.
Conclusions: Study findings supported that CBD interacts with CYP2R1, CYP27B1, CYP24A1, and vitamin D receptors, resulting in increased vitamin D3 metabolites, which improved memory, pain tolerance, reduced inflammation, and aging through modulating antioxidative enzymes, cytokines, and neurotransmitters in VDD-induced rats.
Creator
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Mahendra Kumar Trivedi Sambhu Mondal, Mayank Gangwar, Snehasis Jana
Source
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<a href="https://www.liebertpub.com/doi/abs/10.1089/can.2021.0240?journalCode=can">https://www.liebertpub.com/doi/abs/10.1089/can.2021.0240?journalCode=can</a>
Publisher
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Mary Ann Liebert
Date
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19-Apr-2022
Language
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English
Type
The nature or genre of the resource
Journal Article
cannabidiol
CYP-450-mRNA
Morris water Maze
VDR
Vitamin D3 deficiency diet
Vitamin D3 Metabolites