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Website
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<a href="https://www.trivedieffect.com/science/role-of-vital-trace-elements-in-nanocurcumin-centered-formulation-a-novel-approach-to-resuscitate-the-immune-system">https://www.trivedieffect.com/science/role-of-vital-trace-elements-in-nanocurcumin-centered-formulation-a-novel-approach-to-resuscitate-the-immune-system</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Role of Vital Trace Elements in Nanocurcumin-Centered Formulation: A Novel Approach to Resuscitate the Immune System
Subject
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Nutraceuticals
Description
An account of the resource
<p style="text-align:justify;">The present paper described the immunomodulatory potential of novel nanocurcumin-based formulation enriched with trace elements and vitamins on cyclophosphamide-induced immunosuppression in rat model. Major immune-related assays were monitored such as hemagglutination assay, delayed-type hypersensitivity (DTH) reaction, cellular immune response, IgG, IgE, IgM, cerebrospinal fluid biomarkers, hematological study, antioxidant profile, and lipid biomarkers. Chemical characterization of novel formulation showed retention time (R t ) 18.98 of curcumin, while LC-MS data revealed the presence of the curcumin mass at m/z 369.01 [M + H]+ (calculated for C21H21O6 +, 369.13). This novel formulation exhibited significantly (p ≤ 0.001) increased primary and secondary antibody titer by 72.41% and 33.25%, respectively, while DTH response being improved by 87.50% (p ≤ 0.01). However, CD4+, CD8+, and CD28+ counts were significantly (p ≤ 0.05) increased by 76.46%, 68.21%, and 19.29%, respectively, while the concentrations of IgE, IgM, and IgG were significantly (p ≤ 0.05) increased by 40%, 28.43%, and 38.75%, respectively. CSF biomarkers analysis showed a decreased level of corticosterone, dopamine, serotonin, and tau protein by 29.38%, 51.73%, 29.93%, and 4.87%, respectively. Antioxidant enzymes such as CAT, GPx, and SOD were increased by 43.74%, 49.00%, and 40.84%, respectively, and non-enzymatic component, GSH, was increased by 55.52%. Similarly, free radical LPO was significantly (p ≤ 0.05) decreased by 40.37%, and acute inflammatory marker, MPO concentration, was reduced by 31.14%, compared with the disease control group. In addition, supportive hematology and lipid profile analysis showed promising results with improved overall animal profile. Thus, trace elements in novel formulation can be used in the various pharmacological activities and as dietary supplement due to its wide properties.</p>
Creator
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Mahendra Kumar Trivedi, Mayank Gangwar, Sambhu Charan Mondal, Snehasis Jana
Source
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<a href="https://link.springer.com/article/10.1007%2Fs12011-017-1082-3" target="_blank" rel="noreferrer noopener">https://link.springer.com/article/10.1007%2Fs12011-017-1082-3</a>
Publisher
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Spiringer Link
Date
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July 05, 2017
Language
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English
Type
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Journal Article
Identifier
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10.1007/s12011-017-1082-3
Antioxidant Activity
Cellular and Humoral Immunity
Csf Biomarkers
Free Radical Scavenging
Immunomodulation
Nanocurcumin
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Website
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<a href="https://www.trivedieffect.com/science/immunomodulatory-properties-and-biomarkers-characterization-of-novel-withania-somnifera-based-formulation-supplemented-with-minerals-in-sprague-dawley-rats">https://www.trivedieffect.com/science/immunomodulatory-properties-and-biomarkers-characterization-of-novel-withania-somnifera-based-formulation-supplemented-with-minerals-in-sprague-dawley-rats</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Immunomodulatory properties and biomarkers characterization of novel Withania somnifera based formulation supplemented with minerals in Sprague Dawley rats
Subject
The topic of the resource
Nutraceuticals
Description
An account of the resource
<p style="text-align:justify;">Herbomineral formulations have been accepted world-wide due to its significant therapeutic outcomes. The study aimed to evaluate the immunomodulatory potential of novel herbomineral formulation (TEBEH) on Sprague Dawley rats using cyclophosphamide-induced immunosuppression. Major immune related parameters were monitored such haemagglutination assay, delayed type hypersensitivity reaction, cellular immune response (CD4+ and CD8+), IgG and IgM, hematological analysis, antioxidant profile, and estimation of major lipid biomarkers. The study results suggest herbomineral formulation significantly (p ≤ 0.05) improved the concentration of primary and secondary titre by 41.18 and 68%. However, the rat paw edema at 24 h showed increased edema by 77.78% (p ≤ 0.01). Herbomineral formulation exhibited increase in the CD4+ and CD8+ counts in animals by 28.03 and 60.70%, respectively. In addition, the concentrations of IgM and IgG were improved by 14.29 and 8.26% respectively. Besides, other supportive parameter such as hematology and antioxidant profile was significantly (p ≤ 0.001) improved, while free radical, lipid peroxidation was decreased. Moreover, the major lipid biomarkers were improved such as decreased triglycerides, LDL and VLDL by 15.88, 3.65, and 16.01%, respectively. Overall, the promising results of this study indicated that the herbomineral formulation, TEBEH can be employed to improve the cellular and humoral immunity along with improved hematological, antioxidant, and lipid profile.</p>
Creator
An entity primarily responsible for making the resource
Mahendra Kumar Trivedi, Mayank Gangwar, Sambhu Charan Mondal, Snehasis Jana
Source
A related resource from which the described resource is derived
<a href="https://link.springer.com/article/10.1007/s13596-016-0255-5" target="_blank" rel="noreferrer noopener">https://link.springer.com/article/10.1007/s13596-016-0255-5</a>
Publisher
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Spiringer Link
Date
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January 10, 2017
Language
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English
Type
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Journal Article
Identifier
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10.1007/s13596-016-0255-5
Antioxidant Profile
Cellular and Humoral Immunity
Hematological Parameters
Herbomineral Product
Immunopotentiation
Lipid Profile