Disulfiram is being used clinically as an aid in chronic alcoholism, while nicotinic acid is one of a B-complex vitamin that has cholesterol lowering activity. The aim of present study was to investigate the impact of biofield treatment on spectral properties of disulfiram and nicotinic acid. The study was performed in two groups i.e., control and treatment of each drug. The treatment groups were received Mr. Trivedi’s biofield treatment. Subsequently, spectral properties of control and treated groups of both drugs were studied using Fourier transform infrared (FT-IR) and Ultraviolet-Visible (UV-Vis) spectroscopic techniques. FT-IR spectrum of biofield treated disulfiram showed the shifting in wavenumber of C-H stretching from 1496 to 1506 cm-1 and C-N stretching from 1062 to 1056 cm-1. The intensity of S-S dihedral bending peaks (665 and 553 cm-1) was also increased in biofield treated disulfiram sample, as compared to control. FT-IR spectra of biofield treated nicotinic acid showed the shifting in wavenumber of C-H stretching from 3071 to 3081 cm-1 and 2808 to 2818 cm-1. Likewise, C=C stretching peak was shifted to higher frequency region from 1696 cm-1 to 1703 cm-1 and C-O (COO-) stretching peak was shifted to lower frequency region from 1186 to 1180 cm-1 in treated nicotinic acid. UV spectrum of control and biofield treated disulfiram showed similar pattern of UV spectra. Whereas, the UV spectrum of biofield treated nicotinic acid exhibited the shifting of absorption maxima (λmax) with respect of control i.e., from 268.4 to 262.0 nm, 262.5 to 256.4, 257.5 to 245.6, and 212.0 to 222.4 nm. Over all, the FT-IR and UV spectroscopy results suggest an impact of biofield treatment on the force constant, bond strength, and dipole moments of treated drugs such as disulfiram and nicotinic acid that could led to change in their chemical stability as compared to control.
Disodium hydrogen orthophosphate is a water soluble white powder widely used as pH regulator and saline laxative. The sodium nitrate is a highly water soluble white solid, used in high blood pressure, dentinal hypersensitivity, and production of fertilizers. The present study was aimed to investigate the impact of biofield treatment on spectral properties of disodium hydrogen orthophosphate and sodium nitrate. The study was performed in two groups i.e., control and treatment of each compound. The treatment groups were subjected to Mr. Trivedi’s biofield treatment. The spectral properties of control and treated groups of both compounds were studied using Fourier transform infrared (FT-IR) and Ultraviolet-Visible (UV-Vis) spectroscopic techniques. FT-IR spectrum of biofield treated disodium hydrogen orthophosphate showed the shifting in wavenumber of vibrational peaks (with respect to control) corresponding to O-H stretching from 2975 to 3357 cm-1, PO-H symmetrical stretching from 2359 to 2350 cm-1, O=P-OH deformation from 1717-1796 cm-1 to 1701-1735 cm-1, P=O asymmetric stretching from 1356 to 1260 cm-1 and P=O symmetric stretching from 1159 to 1132 cm-1, etc. Likewise, the FT-IR spectrum of sodium nitrate exhibited the shifting of vibrational frequency of N=O stretching from 1788 to 1648 cm-1 and NO3 asymmetric and symmetric stretchings from 1369 to 1381 cm-1 and 1340 to 1267 cm-1. UV spectrum of treated disodium hydrogen orthophosphate revealed a negative absorbance, it may be due to decrease in UV absorbance as compared to control. UV spectrum of control sodium nitrate exhibited two absorbance maxima (λmax) at 239.4 nm and 341.4 nm, which were altered to one absorbance maxima (λmax) at 209.2 nm after biofield treatment. Overall, the FT-IR and UV spectroscopic data of both compounds suggest an impact of biofield treatment on spectral properties with respect to force constant, bond strength, dipole moments and transition energy between two orbitals (ground state and excited state) as compared to respective control.
Ammonium acetate and ammonium chloride are the white crystalline solid inorganic compounds having wide application in synthesis and analytical chemistry. The aim of present study was to evaluate the impact of biofield treatment on spectral properties of inorganic salt like ammonium acetate and ammonium chloride. The study was performed in two groups of each compound i.e., control and treatment. Treatment groups were received Mr. Trivedi’s biofield treatment. Subsequently, control and treated groups were evaluated using Fourier Transform Infrared (FT-IR) and Ultraviolet-Visible (UV-Vis) spectroscopy. FT-IR spectrum of treated ammonium acetate showed the shifting in wavenumber of vibrational peaks with respect to control. Like, the N-H stretching was shifted from 3024-3586 cm-1 to 3033-3606 cm-1, C-H stretching from 2826-2893 cm-1 to 2817-2881 cm-1, C=O asymmetrical stretching from 1660-1702 cm-1 to 1680-1714 cm-1, N-H bending from 1533-1563 cm-1 to 1506-1556 cm-1 etc. Treated ammonium chloride showed the shifting in IR frequency of three distinct oscillation modes in NH4 ion i.e., at ν1, 3010 cm-1 to 3029 cm-1, ν2, 1724 cm-1 to 1741 cm-1, and ν3, 3156 cm-1 to 3124 cm-1. The N-Cl stretching was also shifted to downstream region i.e., from 710 cm-1 to 665 cm-1 in treated ammonium chloride. UV spectrum of treated ammonium acetate showed the absorbance maxima (λmax) at 258.0 nm that was shifted to 221.4 nm in treated sample. UV spectrum of control ammonium chloride exhibited two absorbance maxima (λmax) i.e., at 234.6 and 292.6 nm, which were shifted to 224.1 and 302.8 nm, respectively in treated sample. Overall, FT-IR and UV data of both compounds suggest an impact of biofield treatment on atomic level i.e., at force constant, bond strength, dipole moments and electron transition energy between two orbitals of treated compounds as compared to respective control.
Metronidazole and tinidazole are widely used antimicrobial drugs against Gram-negative and Gram-positive anaerobic bacteria. The present study was aimed to evaluate the impact of biofield treatment on metronidazole and tinidazole using FT-IR and UV spectroscopy. The study was carried out in two groups i.e. control and treatment. Treatment groups were subjected to Mr. Trivedi’s biofield treatment while no treatment was given to control group. FT-IR spectrum of treated metronidazole showed the impact of biofield treatment on frequency of characteristic functional groups such as C=C (imidazole ring) stretching was appeared at lower frequency i.e. from 1600 cm-1 to 1553 cm-1. Likewise, NO2 asymmetric stretching and C-N symmetric stretching were appeared at higher wave number i.e. 1479 cm-1 to 1501 cm-1 and 1070 cm-1 to 1077 cm-1, respectively. FT-IR spectrum of tinidazole showed shifting in absorption peak of C-N stretching to higher wavenumber from 1002 cm-1 (control) to 1022 cm-1. The wavenumber of aromatic C=C bond (in imidazole) was shifted to lower frequency, which could be due to increases in conjugation effect. Further, increases in wavenumber of NO2 and C-N in treated sample suggested the increased force constant and bond strength as compared to control. Because of higher conjugation effect and increased bond strength, the molecule supposed to be more stable. The UV spectra of both metronidazole and tinidazole showed the similar patterns of lambda max (λmax) with respect to their control. The FT-IR results of both drugs suggest that there was an impact of biofield treatment on atomic level of metronidazole and tinidazole, as compared to control.
Paracetamol and piroxicam are non-steroidal anti-inflammatory drugs (NSAIDs), widely used in pain and inflammatory diseases. The present study aimed to evaluate the impact of biofield treatment on spectral properties of paracetamol and piroxicam. The study was performed in two groups (control and treatment) of each drug. The control groups remained as untreated, and biofield treatment was given to treatment groups. Subsequently, spectral properties of both drugs before and after biofield treatment were characterized using FT-IR and UV-Vis spectroscopic techniques. FT-IR data of paracetamol showed N-H amide II bending peak in biofield treated paracetamol, which was shifted to lower wavenumber (1565 to 1555 cm-1) as compared to control. Further, the intensity of vibrational peaks in the range of 1171-965 cm-1 (C-O and C-N stretching) were increased in treated sample of paracetamol as compared to control. Similarly, the FT-IR data of piroxicam (treated) showed increased intensity of vibrational peaks at 1628 (amide C=O stretching), 1576-1560 cm-1 (C=C stretching) with respect to control peaks. Furthermore, vibrational peak of C=N stretching (1467 cm-1) was observed in biofield treated piroxicam. This peak was not observed in control sample, possibly due to its low intensity. Based on FT-IR data, it is speculated that bond length and dipole moment of some bonds like N-H (amide), C-O, and C-N in paracetamol and C=O (amide), C=N, and C=C in piroxicam might be changed due to biofield treatment. The UV spectrum of biofield treated paracetamol showed the shifting in wavelength of UV absorption as 243→248.2 nm and 200→203.4 nm as compared to control. Likely, the lambda max (λmax) of treated piroxicam was also shifted as 328 →345.6 nm, 241→252.2 nm, and 205.2→203.2 nm as compared to control. Overall results showed an impact of biofield treatment on the spectral properties of paracetamol and piroxicam.
Objective: Chloramphenicol and tetracycline are broad-spectrum antibiotics and widely used against variety of microbial infections. Nowadays, several microbes have acquired resistance to chloramphenicol and tetracycline. The present study was aimed to evaluate the impact of biofield treatment for spectroscopic characterization of chloramphenicol and tetracycline using FT-IR and UV-Vis spectroscopy. Methods: The study was performed in two groups (control and treatment) of each antibiotic. The control groups remained as untreated, and biofield treatment was given to treatment groups. Results: FT-IR spectrum of treated chloramphenicol exhibited the decrease in wavenumber of NO2 from 1521 cm-1 to 1512 cm-1 and increase in wavenumber of C=O from 1681 cm-1 to 1694 cm-1 in acylamino group. It may be due to increase of conjugation effect in NO2 group, and increased force constant of C=O bond. As a result, stability of both NO2 and C=O groups might be increased in treated sample as compared to control. FT-IR spectrum of treated tetracycline showed the downstream shifting of aromatic C-H stretching from 3085-3024 cm-1 to 3064-3003 cm-1 and C=C stretching from 1648-1582 cm-1 to 1622-1569 cm-1 and up shifting of C-N stretching from 965 cm-1 to 995 cm-1. It may be due to enhanced conjugation effect in tetracycline, and increased force constant of C-N (CH3) bond of tetracycline as compared to control. The results indicated the enhanced stability of treated tetracycline as compared to control. UV-Vis spectra of biofield treated chloramphenicol and tetracycline showed the similar lambda max (λmax) to their respective control. It revealed that the chromophore groups of both antibiotics remained same as control after the biofield treatment. Conclusion: Based on FT-IR spectroscopic data, it is speculated that due to increase in bond strength and conjugation effect after biofield treatment, the chemical stability of both the drugs might be increased as compared to control.