Assessment of Oral Bioavailability of Vitamin D3 and Its Metabolite, 25-hydroxy (OH) Vitamin D3 in Male Sprague Dawley Rats Following a Single Oral Dose of Biofield Energy Treated Vitamin D3

Assessment of Oral Bioavailability of Vitamin D3 and Its Metabolite, 25-hydroxy (OH) Vitamin D3 in Male Sprague Dawley Rats Following a Single Oral Dose of Biofield Energy Treated Vitamin D3

Health & Wellness

The present study was performed to determine the effects of The Trivedi Effect®-Energy of Consciousness Healing Treatment on vitamin D3 and rats through the pharmacokinetic parameters measurement of both plasma level of vitamin D3 and 25-hydroxy (OH)-vitamin D3 after the oral administration of vitamin D3 in rats. The test item, vitamin D3 was divided into two parts. One part was denoted as the control (without Biofield Energy Healing Treatment), while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment by renowned Biofield Energy Healer, Mahendra Kumar Trivedi. Additionally, one group of animals also received Consciousness Energy Healing Treatment per se by the Healer under similar conditions. Vitamin D3 oral formulations were administrated by oral gavage at a dose of 500 μg per kg in groups viz. G1 (untreated Vitamin D3), G2 (Biofield Energy Treated Vitamin D3) and G3 (Biofield Energy Treated animals received untreated Vitamin D3) group. The results showed that the relative oral exposure (AUC0–t) of vitamin D3 was significantly increased by 155.62% and 111.73% in G2 and G3 groups, respectively as compared to the control group. Biofield Energy Treatment also significantly improved the plasma peak concentration (Cmax) of vitamin D3 by 223.84% and 187.5% in G2 and G3 groups, respectively as compared to the control group. This study results also showed that the relative oral exposure (AUC0–t) of 25-hydroxy (OH)-vitamin D3 (metabolite) was significantly increased by 161.28% and 113.96% in G2 and G3 groups, respectively as compared to the control group (G1). Biofield Energy Treatment also significantly improved the plasma peak concentration (Cmax) of 25-hydroxy (OH)-vitamin D3 by 174.25% and 111.77% in G2 and G3 groups, respectively as compared to the control group. After oral administration, plasma concentrations of active metabolite, 25-hydroxy (OH)-vitamin D3 in all three groups were declined slowly. The mean residence time (MRTlast) and elimination rate constant (Kel) for this metabolite were unaltered in all three groups. These data suggest that Biofield Energy Treated vitamin D3 might be influenced in vivo biological activity of vitamin D3 due to increased plasma exposure (AUC) of both vitamin D3 and metabolite level, 25-hydroxy (OH)-vitamin D3 in rats. There was significant improvement (>100%) of relative oral bioavailability of both vitamin D3 and 25-hydroxy (OH)-vitamin D3 that might be due to the alteration of physicochemical properties and thermal properties of vitamin D3 by the Biofield Energy Treatment. Biofield Energy Healing Treatment could be an innovative strategy that opens new avenues to overcome poorly absorbed pharmaceuticals/nutraceuticals/herbal extracts and can also improve the therapeutic performance of orally active molecules.

Trivedi MK and Jana S

Medwin Publishers

26-Mar-2021

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English

Journal Article

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